Commanders vs Titans odds and prediction for Week 5 matchup

INDIANAPOLIS, IN - OCTOBER 02: Ryan Tannehill #17 hands the ball off to Derrick Henry #22 of the Tennessee Titans during the game against the Indianapolis Colts at Lucas Oil Stadium on October 2, 2022 in Indianapolis, Indiana. (Photo by Michael Hickey/Getty Images)
INDIANAPOLIS, IN - OCTOBER 02: Ryan Tannehill #17 hands the ball off to Derrick Henry #22 of the Tennessee Titans during the game against the Indianapolis Colts at Lucas Oil Stadium on October 2, 2022 in Indianapolis, Indiana. (Photo by Michael Hickey/Getty Images) /
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At 1-3 and losers of three straight games, the Washington Commanders have entered the must-win portion of their schedule. Do yourselves a favor and don’t look at the upcoming schedule, because it’s not pretty. Take the cookie-cutter approach and focus on one game at a time.

On Sunday, the Commanders will welcome Derrick Henry and the surging Tennessee Titans to FedEx Field. The Titans seemed poised for a down year following their dismal season-opening loss to the Giants and getting trounced by Buffalo with the entire country watching on Monday Night Football in Week 2.

Of course, the Titans are well-coached by Mike Vrabel and they’ve since responded by winning two games on the bounce, toppling a talented Raiders squad in Week 3 before dominating Indianapolis on the road this past weekend. After an 0-2 start, Tennessee might just be the AFC South favorites again.

With the Commanders and Titans heading in opposite directions, let’s see what the odds say about Washington’s chances to pick up a win.

Commanders vs Titans Odds Week 5

According to FanDuel, the Commanders open as a +2.5 home underdog. They have -106 odds to cover the spread and are +122 to win outright on the moneyline. The Titans, on the other hand, are -114 to win by a field goal or more. Tennessee is favored -144 on the moneyline, so bet $144 to bring home $100.

The over/under for Sunday is set at 42.5. With the way Washington’s offense is performing, it’s no surprise the number is that low. Both sides have -110 odds.

Commanders vs Titans Prediction Week 5

The Commanders actually match up well against the Titans … that is if their run defense holds up against Derrick Henry. The two-time rushing champ started off slow but has found his footing the last two games. In Week 2, Henry totaled 85 rushing yards and a touchdown on 4.5 yards per carry. In Week 3, he erupted for 114 yards and a score on 5.18 YPC vs a normally-stout Colts run defense.

The Titans go as Henry goes. Contain him and the offense sputters. Let him find a groove and Tennessee will control the game. It’s usually not that simple in the NFL, but it is with the Titans. Henry is the heart and soul of their offense. Put Ryan Tannehill in a position to win the game and you like your chances.

The million-dollar question is if you trust Washington to execute that game plan. Until proven otherwise, we’re not getting our hopes up. We’d love nothing more than to be proven wrong, but we can’t unsee what transpired these last two games.

Titans 24, Commanders 20.

Game odds refresh periodically and are subject to change.